SUFLAVE™ (polyethylene glycol 3350, sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride for oral solution) is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults.DOSAGE AND ADMINISTRATION
A low residue breakfast may be consumed on the day before colonoscopy, followed by clear liquids up to 2 hours prior to colonoscopy. Administration of two doses of SUFLAVE are required for a complete preparation for colonoscopy. Each bottle must be reconstituted with water before ingestion. Each bottle and one flavor enhancing packet are equivalent to one dose. An additional 16 ounces of water must be consumed after each dose. Stop consumption of all fluids at least 2 hours before the colonoscopy.CONTRAINDICATIONS
Use is contraindicated in the following conditions: gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, hypersensitivity to any ingredient in SUFLAVE.WARNINGS AND PRECAUTIONS
Risk of fluid and electrolyte abnormalities: Encourage adequate hydration,
assess concurrent medications and consider laboratory assessments prior to and after each use; Cardiac arrhythmias: Consider pre-dose and
Most common adverse reactions (≥2%) are: nausea, abdominal distension, vomiting, abdominal pain, and headache.DRUG INTERACTIONS
Drugs that increase risk of fluid and electrolyte imbalance.
1. Bhandari R, Goldstein M, Mishkin DS, et al. Comparison of a novel, flavor-optimized, polyethylene glycol and sulfate bowel preparation with oral sulfate solution in adults undergoing colonoscopy [published ahead of print July 24, 2023]. J Clin Gastroenterol. doi:10.1097/MCG.0000000000001894 2. Bhandari R, Goldstein M, McGowan J, et al. A safety and efficacy comparison of new BLI4900 bowel preparation to oral sulfate solution. Poster Sa1024 presented at: Digestive Disease Week Annual Meeting; May 21-24, 2022; San Diego, California.https://www.emedevents.com/medical-hybrid-events-2022/digestive-disease-week-ddw-conference-2022. 3. Data on file, Braintree, MA: Braintree Laboratories, Inc. 4. SUFLAVE [package insert]. Braintree, MA: Braintree Laboratories, Inc.